Spindle epithelial tumor with thymus-like differentiation involving the parathyroid gland: A case report with literature review

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare benign lesion characterized by the presence of spindle and epithelioid cells and features resembling thymic tissue. A 35-year-old asymptomatic female with a history of two cesarean sections and a positive family history of breast cancer underwent a thyroid checkup. Clinical examination revealed a normal thyroid gland, while diagnostic tests indicated a solid hypoechoic nodule in the right lower parathyroid gland, which was confirmed as SETTLE after surgical resection was performed, leading to an uneventful postoperative period.

The patient, discharged on the first postoperative day, underwent comprehensive follow-up and oncology referral for risk stratification. In the literature review of nine cases of SETTLE (seven male, two female), age (8–70 years), past medical and surgical history of the majority is not available, most of them …