Unilateral breast Darier disease: A case report and literature review

Darier disease is often an underrecognized, disfiguring skin condition. Although the localized form of this condition has been reported in several parts of the body, the present study describes the case of a patient with the unique involvement of one breast, destroying the nipple. A 35-year-old female patient complained of having a right nipple lesion for 1 month.

There were multiple small brown-to-black firm nipple lesions causing nipple destruction, associated with multiple small red, non-tender skin lesions in the areolar region and lower part of the breast. An incisional biopsy revealed a small number of acantholytic cells and a papillary-like configuration within the epidermis; no conclusive evidence of malignancy was observed, and a diagnosis of Darier disease was made. Emollient lotion, topical fusidic acid cream 2%, and oral isotretinoin 20 mg once daily were prescribed.

The proposed pathogenesis of localized …