Overview
While Papillary Thyroid Carcinoma (PTC) is generally known for its favorable prognosis, it can harbor a rare and challenging clinical variant: Squamous Differentiation (PTC-SD).
Key findings
Papillary thyroid carcinoma with squamous differentiation (PTC-SD) is an extremely rare and aggressive variant that requires specific immunohistochemistry markers (such as CK5/6 and p40) for accurate diagnosis and distinction from other conditions.