Psammoma bodies in a benign thyroid gland: A case report and brief review of the literature

Psammoma bodies (PBs) are round, layered calcified structures usually associated with papillary thyroid cancer and may be observed in 40-50% of cases, but may rarely occur in benign thyroid disease. The present study describes a rare case of PBs being found in a benign thyroid gland. In addition, a brief review of the literature is presented.

A 28-year-old female patient presented with a 3-month history of weight loss, poor appetite and generalized weakness. Her thyroid was firm and mildly enlarged. Thyroid function was within normal limits (thyroid-stimulating hormone, 0.85 µIU/ml; free T4, 20.1 pmol/l; thyroglobulin, 6.15 ng/ml).

An ultrasound demonstrated bilateral TI-RADS-3 nodules measuring 25x21x19 mm (right) and 17x15x13 mm (left). A total thyroidectomy revealed thyroid follicular nodular disease with focal lymphocytic thyroiditis and PBs, but no malignancy. In the literature, 4 cases of PBs or …