Primary thyroid non-Hodgkin B-cell lymphoma: a case series

MethodsThis retrospective case series was conducted at a single center from January 2020 to November 2024, including patients diagnosed with B-cell NHL of the thyroid who underwent surgical intervention. Data, including clinical, demographic, laboratory, and imaging information, were extracted from medical records. Diagnostic procedures involved core needle or surgical biopsy with immunohistochemistry analysis.

Treatment included excisional biopsy, thyroidectomy, lobectomy, and chemotherapy. Quantitative data is presented as means and standard deviations, and qualitative data as frequencies and percentages.ResultsAmong nine NHL cases, seven (77.8%) were female, with a mean age of 60.78±12.53 years. Anterior neck swelling was the most common presentation in 6 (66.7%) cases.

Seven patients (77.8%) received R-CHOP chemotherapy; histopathology confirmed B-cell lymphoma in eight cases (88.9%). Thyroid function was euthyroid in four cases (44.4%), hypothyroid in three (33.3%), and hyperthyroid in one (11.1%). TI-RADS (Thyroid Imaging Reporting and Data Systems) classification showed five cases (55.6%) as TI-RADS 5.

Follow-up revealed no recurrence in four cases (44.4%), and two deaths (22.2%).ConclusionPrimary thyroid NHL is a rare condition requiring early diagnosis and personalized treatment. The variability in treatment responses highlights the need for individualized approaches to optimize patient outcomes.