Aberrant metastasis of invasive pleomorphic lobular carcinoma: A case report and brief review of the literature

Pleomorphic lobular carcinoma (PLC) is a rare type of invasive lobular carcinoma. It is more aggressive and is associated with a poorer prognosis, and distinct cytologic characteristics. The present study reports a rare case of invasive PLC metastasis to the peritoneum and ovaries, and also performs a brief review of the literature.

A 51-year-old woman with a family history of breast cancer presented with multiple right breast masses and right axillary lymphadenopathy. Imaging and biopsy confirmed invasive PLC, which was estrogen receptor (ER)/progesterone receptor (PR)-positive and human epidermal growth factor receptor 2 (HER2)-negative, with metastatic involvement of the axillary lymph nodes. Laparoscopy and immunohistochemistry revealed bilateral ovarian and peritoneal metastases.

The patient was diagnosed with metastatic PLC of breast origin. A multidisciplinary team initiated systemic therapy with …