Carcinoma in Situ Raised from Fibroadenoma: A Case Series of a Rare Combination

Introduction Fibroadenomas are the most frequent cause of palpable breast lumps in young women. Although it’s a benign lesion, malignancy can occur in extremely rare cases; this risk is higher in complex fibroadenomas and in patients with a family history of the disease. The aim of the current study is to report a case series of rare combination of two breast tumors (carcinoma in situ within fibroadenoma).

Methods This is a retrospective case series study. The cases were managed in a single private center specific for breast diseases. They were evaluated and treated during the four previous years (January 2018-May 2022).

It included all patients who had a fibroadenoma with malignant changes. Results The study included nine cases. The mean age was 41 years ranged from 31 to 51 years.

Six cases were ductal carcinoma in situ within fibroadenoma and three cases were lobular carcinoma in situ. Conclusion Although fibroadenomas are the most common benign breast mass, it is rarely associated with malignant transformation.